Target of replication: *A priori* experimental protocols, materials, and confirmatory analysis plans were peer reviewed, [pre-registered][1], and published by [*eLife*][2]. This component includes all primary and QC data for the first three protocols of the replication of [Liu et al. 2011][3]. These experiments include: ### Contents ### [Figures component][4], contains a visualization of the results. These figures are the same as can be found in the Replication Study and include Figure 1 and Figure 1 - figure supplement 1, which display miR-34a expression and Flow cytometry gating strategy, respectively. [Data Component][5], contains data generated from the experimental work related to the first three protocols which relate to the Expression of miR-34a in LAPC4 sub-populations. [Methods Component][6], contains the methods relating to the first three protocols. [Maintenance and purification of LAPC4 xenograft prostate tumors Component][7] [Quality Control Component][8], contains the results of both STR profiling and mycoplasma testing related to these protocols. [1]: https://osf.io/4psr3/ [2]: https://elifesciences.org/articles/06434 [3]: http://www.nature.com/articles/nm.2284 [4]: https://osf.io/grva2/wiki/home/ [5]: https://osf.io/5u9ed/wiki/home/?edit&view&menu [6]: https://osf.io/exq24/wiki/home/?edit&view&menu [7]: https://osf.io/4f3rq/wiki/home/?edit&view&menu [8]: https://osf.io/6u42f/wiki/home/?edit&view&menu