**Figure 3. Maximal tolerated dose in an I-BET151 treated xenograft mouse model of MLL-fusion leukaemia.** Female NOD-SCID mice were conditioned with Busulfan and intravenously injected with 1x10⁷ MV4;11 cells in vehicle (PBS). Once disease was established (detectable MV4;11 cells from retro-orbital bleeds), mice were randomized into four cohorts and received daily IP injections of vehicle control [n=5], 10 mg/kg I-BET151 [n=5], 20 mg/kg I-BET151 [n=5], or 30 mg/kg I-BET151 [n=5]. The animals were monitored and their weight was measured for the duration of the 21 day treatment. The Y axis represents mouse weight in grams, the X axis represents days since the start of treatment. Access the [full size image][1] and [R script][2] used to generate this figure. This script will call the [data][3] directly from the OSF. **Figure 3 - figure supplement 1. Maximal tolerated dose in an I-BET151 treated xenograft mouse model of MLL-fusion leukaemia.** This is the same experiment as in Figure 3. Female NOD-SCID mice xenotransplanted with MV4;11 cells were randomly assigned to receive daily IP injections of treatment. At the time of sacrifice, disease burden was evaluated in peripheral blood (PB), bone marrow (BM), and spleen cells. Number of mice analyzed: n=5 for vehicle group, n=5 for I-BET151 10 mg/kg group, n=5 for I-BET151 20 mg/kg, and n=5 for I-BET151 30 mg/kg. (**A**) Dot plot representing the percent of MV4;11 as the percent of HLA-A,B,C⁺ cells determined by flow cytometry analyses of the total cell population. Medians reported as crossbars. (**B**) Dot plot representing the absolute number of MV4;11 cells as determined using CountBright absolute counting beads. Medians reported as crossbars. Access the [full size image][4] and [R script][2] used to generate this figure. This script will call the [data][3] directly from the OSF. ---------- [Statistical Analyses component][5] contains R scripts that were used for the analysis. [1]: https://osf.io/ur6f2/ [2]: https://osf.io/gsp8z/ [3]: https://osf.io/agb9a/ [4]: https://osf.io/gxg7d/ [5]: https://osf.io/zs8we/wiki/home/