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Figure 3. Maximal tolerated dose in an I-BET151 treated xenograft mouse model of MLL-fusion leukaemia. Female NOD-SCID mice were conditioned with Busulfan and intravenously injected with 1x107 MV4;11 cells in vehicle (PBS). Once disease was established (detectable MV4;11 cells from retro-orbital bleeds), mice were randomized into four cohorts and received daily IP injections of vehicle control [n=...

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