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The negative impact of SARS-CoV-2/COVID-19 pandemic and its implications on most people’s psychological functioning, quality of life and satisfaction with life is undeniable (Pfefferbaum & North, 2020). Considering that some areas have been considerably more affected by COVID-19 than others, it is essential to assess possible differences in impact of SARS-CoV-2/COVID-19 pandemic for individuals living in different regions of the globe, namely the United States and Portugal, Furthermore, we intend to examine the putative protective aspect of psychological flexibility in relation to the quality of psychological adjustment.