Target of replication: *A priori* experimental protocols, materials, and confirmatory analysis plans were peer reviewed, [pre-registered][1], and published by [*eLife*][2]. This component includes all data, analysis scripts, and methods for the replication of the experiment reported in Figure 2A and Supplementary Figure 11A-B of [Dawson et al., 2011][3]. This experiment evaluates the selective inhibition of a MLL-fusion leukaemic cell line with I-BET151. [Figures component][4] contains a visualization of replication results. These figures are the same as can be found in the Replication Study and include Figure 1 displaying the dose response curves of cell lines treated with I-BET151. These scripts will call data directly from the OSF. [Statistical Analyses component][5] contains R scripts that were used for the analysis. These scripts will call data directly from the OSF. [Data component][6] contains data generated from the experimental work and files used in the analysis and generation of figures, which are in .csv format. [Methods component][7] contains methodology details for this replication attempt which were described in the [Registered Report][8]. [Cell line quality control data][9] includes results confirming the cells lines was free from mycoplasma contamination as well as STR DNA profiling of the cell lines used. [1]: https://osf.io/kfx9p/ [2]: https://elifesciences.org/content/4/e08997 [3]: https://www.nature.com/nature/journal/v478/n7370/full/nature10509.html [4]: https://osf.io/dqr3g/wiki/home/ [5]: https://osf.io/mj9v3/wiki/home/ [6]: https://osf.io/sg7bm/wiki/home/ [7]: https://osf.io/w9y8u/wiki/home/ [8]: https://elifesciences.org/content/4/e08997 [9]: https://osf.io/vb9q4/wiki/home/