Non-Human Primate Neuroimaging and Neuroanatomy Project (NHP_NNP) project investigates the association of the neuroimaging-based brain connectome with genetic polymorphism and social behaviors.
- For the social behaviors of marmosets, we perform reliable assessments by an well-established personality rating scale, Hominoid Personality Questionnaire (Weiss, Am J Primatol 2009, Weiss Proc Biol Sci 2017), which proved to be reproducibly correlated with other biological markers and genotyping in marmosets (Inoue-Murayama et al. 2018, Weiss et al., BioRxiv).
- For macaque in which most of the data is collected in a short stay (less than 3 weeks), we analyze ‘gaze-sensitivity’, which is known to be a hallmark of adaptive, social behaviors interacting with others (Davidson & Slayton 2016).
- For genotyping in macaque and marmosets, buccal swabs are obtained from each animal and analyzed as described previously (Inoue-Murayama et al 2018), in which the target DNA fragments were chosen from those that are associated with neurotransmission of dopamine, serotonin, oxytocin and vasopressin as previously (Inoue-Murayama et al., 2010, Staes et al 2019).
- Hair samples are also obtained for analyzing the cortisol level (Yamanashi et al. MethodsX 2016) as a marker of chronic stress (Yamanashi et al., 2013, Inoue-Murayama et al 2018).