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# New Tics project # This component maintains publicly available information on [the New Tics project][1], including publications, protocol, and registered analysis plans. ## Selected publications ### Overview * [**The New Tics study**: A novel approach to pathophysiology and cause of tic disorders]( [*a 2020 summary of the project's goals and early results*] ### Clinical findings * [Exploring behavioral markers predicting one-year tic outcome in children with recent-onset tics (2019 AACAP annual meeting)]( * [Provisional Tic Disorder is not so transient]( * [Tic suppression in children with recent-onset tics predicts 1-year tic outcome]( * [Patterns and predictors of tic suppressibility in youth with tic disorders]( * [Case Report: DSM–5 misses an edge case in tic disorders nosology [*version 1; peer review: 2 approved*]]( * [Tic prevalence by direct observation in an elementary school]( * [Functional tic-like presentations differ strikingly from Provisional Tic Disorder [*version 1; peer review: awaiting peer review*]]( ### Other research findings * [Atypical functional connectivity in Tourette Syndrome differs between children and adults]( * [Age-dependent differences in functional brain networks are atypical in Tourette syndrome]( * [Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up]( * [Fractality of tics as a quantitative assessment tool for Tourette syndrome]( * [Reward enhances tic suppression in children within months of tic disorder onset]( * [A voxel-based morphometry study of Provisional Tic Disorder (poster from 2022 [TAA] Tourette Conference, Minneapolis, MN, 15 May 2022 )]( * [Predicting clinical course from subcortical shape in Provisional Tic Disorder]( ### Research tools * [TicTimer software for measuring tic suppression [*version 2; peer review: 2 approved*]]( * [TicTimer Web: software for measuring tic suppression remotely [*version 2; peer review: 2 approved*]]( ### Review articles * [Provisional Tic Disorder: What to tell parents when their child first starts ticcing [*version 1; peer review: 3 approved*]]( * [Neurobiology of the premonitory urge in Tourette’s syndrome: Pathophysiology and treatment implications]( * [Recent progress on Tourette syndrome]( * [A comprehensive review of tic disorders in children]( * [Course of tic disorders over the lifespan]( (free preprint available [here]( * [Correlates and clinical implications of tic suppressibility]( (free preprint available [here]( * [Predictors of tic symptom evolution after first onset (presentation at the 2022 AACAP/CACAP annual meeting)]( * [Diagnosis and management of functional tic-like phenomena]( ## Miscellaneous ### * [This project, on]( * [This project, on the NIH web site]( * A [recruitment flyer online][2] from when we were actively recruiting. Recruitment is now closed. ## Registered protocols [`research_plan_20160705.pdf`]( the R01 application submitted to NIH for the July, 2016, deadline, containing the key 5 pre-specified hypotheses to be tested with new data and a description of the analysis plan ## Final protocol * [`NewTicsR01_Protocol_20200312.pdf`]( current protocol   [1]: [2]: "the New Tics project"
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