# New Tics project # This component maintains publicly available information on [the New Tics project][1], including publications, protocol, and registered analysis plans. ## Selected publications ### Overview * [**The New Tics study**: A novel approach to pathophysiology and cause of tic disorders](https://jpbs.hapres.com/htmls/JPBS_1245_Detail.html) [*a 2020 summary of the project's goals and early results*] ### Clinical findings * [Exploring behavioral markers predicting one-year tic outcome in children with recent-onset tics (2019 AACAP annual meeting)](https://doi.org/10.1016/j.jaac.2019.08.146) * [Provisional Tic Disorder is not so transient](https://doi.org/10.1038/s41598-019-40133-4) * [Tic suppression in children with recent-onset tics predicts 1-year tic outcome](https://doi.org/10.1177/0883073819855531) * [Patterns and predictors of tic suppressibility in youth with tic disorders](https://www.frontiersin.org/articles/10.3389/fpsyt.2018.00188/abstract) * [Case Report: DSM–5 misses an edge case in tic disorders nosology [*version 1; peer review: 2 approved*]](https://doi.org/10.12688/f1000research.23991.1) * [Tic prevalence by direct observation in an elementary school](https://osf.io/bv86n/) * [Functional tic-like presentations differ strikingly from Provisional Tic Disorder [*version 1*]](https://doi.org/10.12688/f1000research.129252.1) * [We’ve all been wrong about Provisional Tic Disorder](https://doi.org/10.1016/j.comppsych.2024.152510) ### Other research findings * [Atypical functional connectivity in Tourette Syndrome differs between children and adults](https://doi.org/10.1016/j.biopsych.2019.06.021) * [Age-dependent differences in functional brain networks are atypical in Tourette syndrome](https://doi.org/10.1101/2020.04.06.20049817) * [Hippocampal volume in Provisional Tic Disorder predicts tic severity at 12-month follow-up](https://doi.org/10.3390/jcm9061715) * [Fractality of tics as a quantitative assessment tool for Tourette syndrome](https://royalsocietypublishing.org/doi/full/10.1098/rsif.2021.0742) * [Reward enhances tic suppression in children within months of tic disorder onset](http://dx.doi.org/10.1016/j.dcn.2014.08.005) * [A voxel-based morphometry study of Provisional Tic Disorder (poster from 2022 [TAA] Tourette Conference, Minneapolis, MN, 15 May 2022 )](https://osf.io/nmjxc) * Correlating clinical course with baseline subcortical shape in Provisional Tic Disorder. CNS Spectrums [in press]. [Early preprint available here](https://doi.org/10.1101/2021.11.04.21265815) * [Cortical thickness in provisional and chronic tic disorder (preprint, v. 1.1)](https://zenodo.org/doi/10.5281/zenodo.13716948) * [Older version: slides from TAA's TIC-CON 2024 Research Symposium, Dallas, TX, 31 May 2024](https://osf.io/y5vxj/files/osfstorage/66609f3177ff4c5051e04669) ### Research tools * [TicTimer software for measuring tic suppression [*version 2; peer review: 2 approved*]](http://doi.org/10.12688/f1000research.12327.2) * [TicTimer Web: software for measuring tic suppression remotely [*version 2; peer review: 2 approved*]](https://doi.org/10.12688/f1000research.26347.2) ### Review articles * [Provisional Tic Disorder: What to tell parents when their child first starts ticcing [*version 1; peer review: 3 approved*]](http://dx.doi.org/10.12688/f1000research.8428.1) * [Neurobiology of the premonitory urge in Tourette’s syndrome: Pathophysiology and treatment implications](http://dx.doi.org/10.1176/appi.neuropsych.16070141) * [Recent progress on Tourette syndrome](https://facultyopinions.com/prime/reports/b/10/70/) * [A comprehensive review of tic disorders in children](https://doi.org/10.3390%2Fjcm10112479) * [Course of tic disorders over the lifespan](https://doi.org/10.1007%2Fs40474-021-00231-3) (free preprint available [here](https://doi.org/10.31219/osf.io/vehjr)) * [Correlates and clinical implications of tic suppressibility](https://doi.org/10.1007%2Fs40474-021-00230-4) (free preprint available [here](https://doi.org/10.31219/osf.io/5sg2d)) * [Predictors of tic symptom evolution after first onset (presentation at the 2022 AACAP/CACAP annual meeting)](https://doi.org/10.1016/j.jaac.2022.07.084) * [Diagnosis and management of functional tic-like phenomena](https://doi.org/10.3390/jcm11216470) ## Miscellaneous ### * [This project, on ClinicalTrials.gov](https://clinicaltrials.gov/ct2/show/NCT01177774) * [This project, on the NIH web site](https://reporter.nih.gov/project-details/10198671) * A [recruitment flyer online][2] from when we were actively recruiting. Recruitment is now closed. ## Registered protocols [`research_plan_20160705.pdf`](https://osf.io/cdx3n): the R01 application submitted to NIH for the July, 2016, deadline, containing the key 5 pre-specified hypotheses to be tested with new data and a description of the analysis plan ## Final protocol * [`NewTicsR01_Protocol_20200312.pdf`](https://osf.io/vtj8g/): current protocol   [1]: https://jpbs.hapres.com/htmls/JPBS_1245_Detail.html [2]: http://www.NewTics.info "the New Tics project"