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  1. Birgit Abler
  2. Ingrid Agartz
  3. Torbjörn Åkerstedt
  4. Mia Anthony
  5. Katja Bertsch
  6. Rebecca C. Brown
  7. Romuald Brunner
  8. Eco J.C. de Geus
  9. Isabel Dziobek
  10. Simon Guendelman
  11. Sabine C. Herpertz
  12. Michael Kaess
  13. Tobias Kaufmann
  14. Marlene Krauch
  15. Feng Lin
  16. Elena Makovac
  17. Matteo Mancini
  18. Falk Mancke
  19. Bryon Mueller
  20. Vera Muench
  21. Frauke Nees
  22. Daniela Ordonez Acuna
  23. Brenda W.J.H. Penninx
  24. Allison Ponzio
  25. Govinda R. Poudel
  26. Janis Reinelt
  27. Ping Ren
  28. Lin Sørensen
  29. Joana Straub
  30. Julian F. Thayer
  31. Benjamin Ubani
  32. Laura S. van Velzen
  33. David R. Watson
  34. Luqing Wei
  35. Melinda Westlund Schreiner

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Category: Project

Description: Resting state autonomic nervous system activity [ANS] indexed by measures of heart rate [HR] and its variability [HRV], is associated with brain morphology, in particular cortical thickness [CT]. However, findings have been mixed regarding the regions of interest [ROI] associated with HR/HRV and the direction of the association. Sex and age differences in HR/HRV and CT may explain some of the existing inconsistencies. Understanding the association between ANS function and brain morphology across aging, may provide important insights into neurovisceral mechanisms underlying health and disease. Previous studies have been limited by small sample sizes, prohibiting the assessment of sex differences, and effects of aging, in the association between ANS function and CT. In an effort to overcome these limitations, data from researchers worldwide, applying similar protocols in the assessment of CT and recording of HR/HRV, will be pooled for a mega-analysis. This preprint details the hypotheses, strategies for pooling of data and planned analyses of this project.

License: CC0 1.0 Universal


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