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  1. Birgit Abler
  2. Ingrid Agartz
  3. Mia Anthony
  4. Katja Bertsch
  5. Rebecca C. Brown
  6. Romuald Brunner
  7. Eco J.C. de Geus
  8. Simon Guendelman
  9. Sabine C. Herpertz
  10. Michael Kaess
  11. Tobias Kaufmann
  12. Marlene Krauch
  13. Feng Lin
  14. Elena Makovac
  15. Matteo Mancini
  16. Falk Mancke
  17. Bryon Mueller
  18. Vera Muench
  19. Frauke Nees
  20. Daniela Ordonez Acuna
  21. Brenda W.J.H. Penninx
  22. Allison Ponzio
  23. Govinda R. Poudel
  24. Janis Reinelt
  25. Ping Ren
  26. Joana Straub
  27. Julian F. Thayer
  28. Benjamin Ubani
  29. Laura S. van Velzen
  30. David R. Watson
  31. Luqing Wei
  32. Melinda Westlund Schreiner

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Category: Project

Description: Resting state autonomic nervous system activity [ANS] indexed by measures of heart rate [HR] and its variability [HRV], is associated with brain morphology, in particular cortical thickness [CT]. However, findings have been mixed regarding the regions of interest [ROI] associated with HR/HRV and the direction of the association. Sex and age differences in HR/HRV and CT may explain some of the existing inconsistencies. Understanding the association between ANS function and brain morphology across aging, may provide important insights into neurovisceral mechanisms underlying health and disease. Previous studies have been limited by small sample sizes, prohibiting the assessment of sex differences, and effects of aging, in the association between ANS function and CT. In an effort to overcome these limitations, data from researchers worldwide, applying similar protocols in the assessment of CT and recording of HR/HRV, will be pooled for a mega-analysis. This preprint details the hypotheses, strategies for pooling of data and planned analyses of this project.

License: CC0 1.0 Universal


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