This component includes data and analysis scripts for the meta-analyses of the effects from the experiment reported in Figures 3D and 4B of [Dawson et al., 2011][1] and the replication of these experiments.
**Figure 5. Meta-analyses of each effect.** Effect size and 95% confidence interval are presented for Dawson et al., 2011, this replication study (RP:CB), and a random effects meta-analysis of those two effects. Sample sizes used in Dawson et al., 2011 and this replication attempt are reported under the study name. (**A**) Fold _BCL2_ expression in K-562 cells compared to a constant of 1 (DMSO) (meta-analysis _p_ = .011), and fold _BCL2_ expression in MV4;11 cells compared to a constant of 1 (DMSO) (meta-analysis _p_ = .037). (**B**) Fold _BCL2_ expression in MV4;11 cells compared to the fold _BCL2_ expression in K-562 cells (meta-analysis _p_ = .001). (**C**) HR for mice treated daily with I-BET151 compared to vehicle control (meta-analysis _p_ = .038).
Access the [full size image][2] and [R script][3] used to generate this figure. These scripts will call the [data][4] directly from the OSF.
Access the [analysis script][5]. This script will call the data directly from the OSF for the replication data.
[1]: https://www.nature.com/nature/journal/v478/n7370/full/nature10509.html
[2]: https://osf.io/8acw4/
[3]: https://osf.io/62hfj/
[4]: https://osf.io/cq6xe/
[5]: https://osf.io/m8hzn/