Within the United States, Latinx urban teens often experience high rates of community violence exposure (CVE). Yet, there is little research that ties the cultural value of Familismo-a commonly held value in the Latinx population which may act as a protective factor in the context of CVE-with symptoms of post-traumatic stress disorder (PTSD). In this study, we examine if greater Familismo moderates the relationship between CVE and PTSD symptoms using mixed-methods. We recruited 416 Latinx teens (Mage=15.5) from the Midwest urban U.S. Quantitative results indicated that higher levels of CVE were associated with greater PTSD symptoms and higher Familismo was associated with lower PTSD symptoms. However, Familismo did not moderate the association between CVE and PTSD symptoms. Yet, while the quantitative data did not test the relationship between CVE and Familismo, qualitative data shows that teens with greater Familismo are impacted more by CVE. Instead of protecting, familismo may intensify the relationship between CVE and PTSD. Though Familismo can be protective, our results suggest that the influence of context on Familismo is important as a potential point of intervention.