Oncolytic Virus for Cholesteatoma Treatment

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Description: This project proposes to develop an oncolytic herpes simplex virus (oHSV) that expresses human tissue inhibitor of metalloproteinases 3 (TIMP3), for treatment of cholesteatomas (CHSTs). We are currently asking the open science community to validate the feasibility of our engineered oHSV as a novel approach for CHST treatment. If you have questions as you proceed, Microbial Robotics staff are available to answer questions and assist with problems that may arise. Please, contact us at jin.kong@microbialrobotics.com for this purpose. Currently, this project is open and any contribution you make will be made available to the public via CC BY (Creative Commons) license - meaning you are attributed as the originator but others have rights to reuse and modify your copyrighted content. We hope to learn of your experience with our new biomarker through your public conference presentations and peer-reviewed publications. Essential information for conducting analyses is provided below.

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Problem: Cholesteatomas (CHSTs) are invasive lesions of the temporal bone, skull base, and intracranial cavity primarily affecting the middle ear and can cause deafness, dizziness, facial nerve paralysis, brain abscess, meningitis, and death. CHSTs currently are treated only by a costly surgery associated with a high (15-70%) recurrence rate and risk of complications. Solution: The goal of the ...

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