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Description: The memory-guided saccade task is an informative saccade paradigm requiring participants to remember the location of a peripheral target, whilst inhibiting the urge to make a saccade to that target ahead of an auditory cue. The literature has explored the endophenotypic deficits associ-ated with differences in target laterality, but less is known about the effects of target amplitude. The data presented in the current research came from Crawford et al. (1995), which employed a memory-guided saccade task among medicated and non-medicated patients with Schizophrenia (n=31, n=12) and Bipolar Affective Disorder (n=12, n=17), compared to neurotypical controls (n=30). The current analyses explore the relationships between memory-guided saccades toward targets with different eccentricities (7.5o and 15o), the discernible behaviour exhibited amongst diagnostic groups, and cohorts distinguished based on symptomatology. Saccade gain control and final eye position was reduced among medicated-schizophrenia patients. These metrics were lessened further among targets with greater amplitudes (15o); indicating greater deficit. The medicated cohort (regardless of diagnosis) exhibited reduced gain control and final eye positions in both amplitudes compared to the non-medicated cohort, but this deficit is markedly observed in the furthest targets. With reference to symptoms (positive and negative), no group differences were reported. However, greater deficit is observed toward the target with the greatest ampli-tude. This suggests that within the memory-guided saccade paradigm, diagnostic classification is more prominent in characterising disparities in saccade performance than symptomatology.