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Description: Mastitis has become a problematic issue in dairy farm for decades which resulted in enormous economic loss. According to clinical sign, mastitis consists of clinical and subclinical mastitis. Clinical mastitis symptoms are including redness and swelling of the udder with sharp onset (Gruet et al., 2001). On the contrary, subclinical mastitis is not characterized by any visible symptoms but characterized by decreasing on milk production and high somatic cell count (SCC) (Khan and Khan, 2006; Tančin and Uhrinčat, 2014). The reduction of milk production in reportedly more severe in clinical mastitis but the rate of subclinical mastitis is 15-40 times higher with longer infection time than clinical mastitis. In addition, subclinical mastitis is harder to detect and infected animal can play a role as reservoir to other animals (Cobirka et al., 2020). In addition to reduction of milk yield and compromise the milk component including reduction in protein, lactose, and fat (Wahyu Harjanti and Sambodho, 2020). In the past years, in developed countries, many developments in farming management system have been implemented which results in reduction of mastitis cases, especially the contagious one. However, in developing countries, mastitis is still high which dominated by subclinical mastitis which persistent and chronic (Cobirka et al., 2020). Similar condition is found in Indonesia; many studies has a cases with high prevalence of subclinical mastitis. The prevalence of subclinical mastitis in Indonesia is reported to be ranging from 46.41%-85% (Sutarti et al., 2012; Wicaksono and Sudarwanto, 2016; Windria et al., 2016; Effendi et al., 2019; Khasanah and Widianingrum, 2021). However, to the best of our knowledge, the studies of mastitis in Indonesia is based on regional or location and has not been reviewed systematically so that the complete understanding on mastitis prevalence in Indonesia in unavailable. The protocol is developed to describe the methodology in reviewing and analyze the data using systematic review and meta-analysis.


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