Multi-Trait Analysis of GWAS and Biological Insights to Cognition: A response to Hill (2017)

  1. Max Lam
  2. Emma Knowles
  3. Srdjan Djurovic
  4. Ingrid Melle
  5. Kjetil Sundet
  6. Andrea Christoforou
  7. Ivar Reinvang
  8. Pamela DeRosse
  9. Astri J. Lundervold
  10. Vidar M. Steen
  11. Thomas Espeseth
  12. Katri Raikkonen
  13. Elisabeth Widen
  14. Aarno Palotie
  15. Johan G. Eriksson
  16. Ina Giegling
  17. Bettina Konte
  18. Panos Roussos
  19. Stella Giakoumaki
  20. Katherine E. Burdick
  21. Antony Payton
  22. William Ollier
  23. Ornit Chiba-Falek
  24. Deborah K. Attix
  25. Anna C. Need
  26. Elizabeth T. Cirulli
  27. Aristotle N. Voineskos
  28. Nikos C. Stefanis
  29. Dimitrios Avramopoulos
  30. Alex Hatzimanolis
  31. Dan E Arking
  32. Nikolaos Smyrnis
  33. Nelson A. Freimer
  34. Tyrone D. Cannon
  35. Edythe London
  36. Fred W. Sabb
  37. Eliza Congdon
  38. Emily Drabant Conley
  39. Dwight Dickinson
  40. Richard E. Straub
  41. Gary Donohoe
  42. Derek Morris
  43. Aiden Corvin
  44. Michael Gill
  45. Ahmad R. Hariri
  46. Daniel R. Weinberger
  47. Neil Pendleton
  48. Panos Bitsios
  49. Dan Rujescu
  50. Jari Lahti
  51. Stephanie Le Hellard
  52. Matthew C. Keller
  53. Ole A. Andreassen
  54. David C. Glahn
  55. Anil K. Malhotra

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Description: Hill (2017) presented a critique of our recently published paper in Cell Reports entitled “Large-Scale Cognitive GWAS Meta-Analysis Reveals Tissue-Specific Neural Expression and Potential Nootropic Drug Targets” (Lam et al. 2017). Specifically, Hill offered several inter-related comments suggesting potential problems with our use of a new analytic method called Multi-Trait Analysis of GWAS (MTAG; Turley et al. 2017). In this brief paper, we respond to each of these concerns. Using empirical data, we conclude that our MTAG results do not suffer from “inflation of the false discovery rate”, as suggested by Hill (2017), and are not “more relevant to the genetic contributions to education than they are to the genetic contributions to intelligence.”

License: CC-By Attribution 4.0 International


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