DESCRIPTION OF THE BACKCROSS

N2 individuals born to F1 mothers are designated with prefix 1--, where as N2 individuals born to A/J mothers are designated with prefix 8--. A csv file contains the sex and the litter information in R/QTL cross format. All N2 animals are 28 days of age. More details about the breeding scheme, genotyping and imaging can be found in these open access papers:

1. Quantitative trait loci affecting the 3D skull shape and size in mouse and prioritization of candidate genes in-silico
2. Does 3D Phenotyping Yield Substantial Insights in the Genetics of the Mouse Mandible Shape?
3. Genetic mapping of molar size relations identifies inhibitory locus for third molars in mice.

While the papers specify the sample size as 433, this dataset is more inclusive since it contains additional samples which failed the QC for genotyping.

Original scans were done at 17.72 micron resolution and manually annotated at the full resolution. Due to storage constrains, volumes were downsampled 50% to 35 micron resolution, and landmark coordinates appropriately adjusted. If you find a specimen where landmarks don't line up correctly with respect to the skull, please contact me at: maga at uw dot edu and specify the specimen number. Note that image spacing is not specified in the nifti header.

Currently only skull landmarks are available. Mandible landmarks will be added later. Both CT volumes and landmarks can be visualized by loading them into the Slicer, which is freely available at Slicer's webpage.