Lower MR-indexed locus coeruleus integrity in autosomal-dominant Alzheimer’s disease is related to cortical tau burden and memory deficits

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Description: Authors: Martin J. Dahl*[1,2], Mara Mather[2], Markus Werkle-Bergner[1], Briana L. Kennedy[2,3], Yuchuan Qiao[4], Yonggang Shi[4], & John M. Ringman[5] Affiliations: [1] Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany [2] Davis School of Gerontology, University of Southern California, 90089 Los Angeles, CA, USA [3] School of Psychological Science, University of Western Australia, Perth, Australia [4] Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA [5] Department of Neurology, Keck School of Medicine, University of Southern California, 90033 Los Angeles, CA, USA * Corresponding author: MJD (dahl [at] mpib-berlin.mpg.de) We aimed at improving the reliability and validity of MR-based locus coeruleus detection. Leveraging a meta-analytical approach, we aggregated across previously published maps of the locus coeruleus (Betts et al., 2017; Dahl et al., 2019; Keren et al., 2009; Liu et al., 2019; Tona et al., 2017; Ye et al., 2020) to derive a biologically plausible volume of interest (meta mask) that shows high agreement across investigations. We freely share the locus coeruleus meta mask with the scientific community

License: CC-By Attribution 4.0 International

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