Lower MR-indexed locus coeruleus integrity in autosomal-dominant Alzheimer’s disease is related to cortical tau burden and memory deficits
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Description: Authors: Martin J. Dahl* 1,2, Mara Mather 2, Markus Werkle-Bergner 1, Briana L. Kennedy 2,3, Samuel Guzman 4, Kyle Hurth4, Carol A. Miller 4, Yuchuan Qiao 5, Yonggang Shi5, Helena C. Chui 6, & John M. Ringman 6 Affiliations: 1 Center for Lifespan Psychology, Max Planck Institute for Human Development, 14195 Berlin, Germany 2 Davis School of Gerontology, University of Southern California, 90089 Los Angeles, CA, USA 3 School of Psychological Science, University of Western Australia, Perth, Australia 4 Department of Pathology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 5 Laboratory of Neuro Imaging (LONI), USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA 6 Department of Neurology, Keck School of Medicine, University of Southern California, 90033 Los Angeles, CA, USA * Corresponding author: MJD (dahl [at] mpib-berlin.mpg.de) We aimed at improving the reliability and validity of MR-based locus coeruleus detection. Leveraging a meta-analytical approach, we aggregated across previously published maps of the locus coeruleus (Betts et al., 2017; Dahl et al., 2019; Keren et al., 2009; Liu et al., 2019; Tona et al., 2017; Ye et al., 2020) to derive a biologically plausible volume of interest (meta mask) that shows high agreement across investigations. We freely share the locus coeruleus meta mask with the scientific community. For a description of the methods, please see: https://doi.org/10.1101/2020.11.16.20232561