Part-set cuing facilitation and impairment effects were seldom found in spatial memory. The present study constructed two types of memory scenes with high and low degrees of interitem associations by manipulating the presentation of miniatures to examine the effects of different part-set cuing on free recall, recognition, and reconstruction. The results showed that in scenes with a high degree of interitem associations, part-set cuing impairment appeared in free recall and recognition, while part-set cuing facilitation appeared in reconstruction; in scenes with a low degree of interitem associations, there was no cuing effect among the three recall tasks. The analysis of completely correct performance on the three recall tasks revealed the presence of part-set cuing impairment and facilitation effects in scenes with a high degree of interitem associations; in scenes with a low degree of interitem associations, there was a part-set cuing facilitation effect in reconstruction. These results supported the Strategy Disruption Hypothesis and the two-mechanism account, demonstrating the importance of interitem associations in spatial memory and providing evidence for part-set cuing facilitation and impairment effects in spatial memory.