Albarracín and Handley (2011) demonstrated that general action (inaction) goals decrease (increase) the degree pre-existing attitudes change following persuasive information. The current research tested whether action (inaction) goals instead result in more (less) attitude change in response to persuasive information about a novel topic, particularly when initial attitude uncertainty is salient. Participants reported their initial attitudes toward a novel (fictitious) food product called Miniac. Next, depending on random assignment, initial attitude uncertainty was/was not made salient and participants were primed with either an action, inaction, or no goal. Finally, all participants read a persuasive message against Miniac and then reported post-message attitudes. Replicating prior findings, action (inaction) goals resulted in less (more) attitude change following a persuasive message when the uncertainty about participants’ initial relevant attitudes was not salient. But, extending that research in a novel way, this pattern was significantly reversed when initial attitude uncertainty was made salient.