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Galaxies are not isolated and static "Island Universes." Material flows into, within, and out of them via accretion and large-scale fountains and outflows powered by intense star formation episodes (starbursts) and nuclear activity driven by supermassive black holes (AGN). I will summarize the current observational evidence for this "galactic ecosystem" in and around nearby and distant galaxies. Then I will look to the future and discuss how the new radio/millimeter/sub-millimeter-wave facilities planned for the 2020s and beyond should allow us to make significant progress in this area of research.
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