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Description: In this systematic review, we will provide an overview of all reported procedures in mouse studies until 31.12.2019 using surgery that involves the placing of ECG recording telemetry devices and an overview of the methodological quality of all these studies. Furthermore, we will investigate and report the trends in refinements observed until 31.12.2019. Additionally, a comparison will be made between the periods before and after 2010 (when the ARRIVE Guidelines were developed, as a tool to evaluate reporting quality). Lastly, we will investigate the different factors affecting the welfare of the animals after the implantation surgery. The ECG telemetry implantation surgery was chosen among other types of existing telemetric measurements because of its potential increased severity (especially when the device is implanted in the intraperitoneal region of the animal). This way we will achieve to showcase possible refinements that have been applied during the course of time in the field of biotelemetry, and more specifically when ECG recording devices are utilized. In the attached files a detailed protocol can be found (based on the format by SYRCLE, version 2.0) and a file containing the search strategy (with the specific search strings used), that was performed on three databases (PubMed, World of Science and Embase) on 29.02.2020, as well as the number of items found on each database.


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