Measuring the duration of cognitive processing with reaction time is fundamental to several subfields of psychology. Many methods exist for estimating movement initiation when measuring reaction time, but there is an incomplete understanding of their relative performance. The purpose of the present study was to identify and compare the tradeoffs of 19 estimates of movement initiation across two experiments. We focused our investigation on estimating movement initiation on each trial with filtered kinematic and kinetic data. Nine of the estimates involved absolute thresholds (e.g. acceleration 1,000 back to 200 mm/s2, micro push-button switches), and the remaining ten estimates used relative thresholds (e.g. force extrapolation, 5% of maximum velocity). The criteria were the duration of reaction time, immunity to the movement amplitude, responsiveness to visual feedback during movement execution, reliability, and the number of manually corrected trials (efficacy). The three best overall estimates, in descending order, were yank extrapolation, force extrapolation, and acceleration 1,000 to 200 mm/s2. The sensitive micro push-button switch, which was the simplest estimate, had a decent overall score, but it was a late estimate of movement initiation. The relative thresholds based on kinematics had the six worst overall scores. An issue with the relative kinematic thresholds was that they were biased by the movement amplitude. In summary, we recommend measuring reaction time on each trial with one of the three best overall estimates of movement initiation. Future research should continue to refine existing estimates while also exploring new ones.