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Description: Abstract Background: Chronic pelvic inflammatory disease（CPID）is one of common diseases of department of gynaecology, point to female inside genital and circumferential organization to suffer from infection of all sorts of pathogenic bacteria and cause chronic inflammation sex disease, also cause one of main factors of infertile of female of childbearing age period. Due to its insidious onset, it is not easy to find out in the early stage, and most cases have been diagnosed for more than half a year. Therefore, it is difficult to obtain satisfactory curative effect by taking routine treatment with antibiotics. In recent years, TCM has made great strides in the treatment of chronic pelvic inflammation,A number of clinical studies have shown that Guizhi Fuling wan combined with antibiotics can significantly improve the clinical symptoms and enhance the therapeutic effect. Therefore, we intend to conduct a system review to further clarify the effectiveness and safety of GZFLW for CPID. Methods: We will search each database from the built-in until September2020.The English literature mainly searches Cochrane Library, PubMed, EMBASE, and Web of Science, while the Chinese literature comes from CNKI, CBM, VIP, and Wangfang database. Simultaneously we will retrieval clinical registration tests and grey literatures. This study only screen the clinical randomized controlled trials (RCTs) about GZFLW for CPID to assess its efficacy and safety. The 2 researchers worked independently on literature selection, data extraction, and quality assessment. The dichotomous data is represented by relative risk (RR), and the continuous is expressed by mean difference (MD) or standard mean difference (SMD), eventually the data is synthesized using a fixed effect model (FEM) or a random effect model (REM) depending on whether or not heterogeneity exists. The clinical efficacy, pelvic effusion and mass were evaluated as the main outcomes. The serum interleukin-6 (IL-6), C-reactive protein (CRP), tumor necrosis factor（TNF）-α， erythrocyte sedimentation rate (ESR), erythrocyte specific volume were secondary outcomes. Finally, meta-analysis was conducted by RevMan software version 5.3. Results: This study will provide high-quality evidence for treatment of CPID with GZFLW in terms of effectiveness and safety. Conclusion: This systematic review aims to provide new options for GZFLW treatment of CPID in terms of its efficacy and safety. Ethics and dissemination: This study does not require ethical approval. We will disseminate our findings by publishing results in a peer-reviewed journal. OSF registration number: DOI 10.17605/OSF.IO/GZ69F Abbreviations: CPID = Chronic pelvic inflammatory disease, GZFLW = Guizhi Fuling wan, OSF= Open Science Framework,CBM = Chinese biomedical literature database, CNKI = China national knowledge infrastructure, EMBASE = excerpt medica database, RCTs = randomized controlled trials,FEM = fixed effect model, REM = random effect model, SMD = standard mean difference, PRISMAP = preferred reporting items for systematic review and meta-analysis protocols, RR = rate ratio. Keywords: Chronic pelvic inflammatory disease,Guizhi Fuling wan, ,modified Guizhi Fuling wan,protocol, systematic review ,meta analysis.