Targeted Memory Reactivation (TMR) during sleep benefits memory integration and consolidation. Here, we investigated the effects of TMR applied during non-rapid eye movement sleep following modulation and updating of aversive autobiographical memories using imagery rescripting (ImR). During 2-5 nights, 80 healthy participants were repeatedly presented with either idiosyncratic words from an ImR updated memory during sleep (experimental group) or with no or neutral words (control groups) using a wearable EEG. While ImR showed significant effects on all memory characteristics (d = 0.76 – 1.66), there were significant additional improvements in the experimental group. Memories were significantly less vivid and afflicted with less emotional distress and arousal following ImR-words cueing. TMR during sleep in individuals’ homes was feasible and further improved some ImR’s adaptive memory effects. If replicated in clinical samples, TMR may be utilized to augment the effects of ImR and other clinical memory modulation procedures and create personalized treatment options.