**Review Question** Two questions will be addressed in this umbrella review of systematic reviews: 1) What is the association between vision impairment or eye disease and quality of life? 2) What is the impact of ophthalmic interventions on quality of life? **Participants** Systematic reviews of studies with participants who have vision impairment, or an eye disease will be included. Systematic reviews with sample populations from any age group (children, working-age adults, or older adults), country (low, middle or high income), or setting (community, hospital, clinic, institution) will be included. **Interventions** Systematic reviews that examine interventions will also be included and will help answer the second question specifically, the impact of ophthalmic interventions on quality of life. Any ophthalmic intervention identified will be included, as long as its main aim is to correct or improve vision, slow down the progression of vision loss, improve functional ability among those with vision loss, or relieve eye pain or discomfort. **Outcomes** Studies that measure any aspect of quality of life (generic or health-related, vision-related, or disease-specific) will be included. Studies can report on one or all domains used to measure quality of life. **Types of Studies** Only systematic reviews (with or without and meta-analyses) are eligible for inclusion. All other types of reviews, including narrative reviews and scoping reviews will be excluded. **Searches** Search strategies were developed using a combination of controlled vocabulary and keywords to represent vision terms, eye diseases, including all the WHO priority eye disease listed above, and ophthalmic interventions, as well as search terms for quality of life, including some commonly used scales, and terms to identify systematic reviews. The following databases will be searched: Medline Ovid, Embase.com, Cochrane Database of Systematic Reviews, Proquest Dissertations and Theses Global. A search for grey literature will also be performed. The search will be limited to articles published in English with no restrictions on the year of publication. **Study Selection** Review selection will take place at the level of title/abstract and full text. Reviews judged to be of insufficient quality for inclusion will also be excluded at the methodological assessment stage. Systematic reviews and meta-analyses, published in English, and that address a vision-related topic (vision impairment, eye disease, or ophthalmic intervention) and quality of life will be included. **Assessment of Methodological Quality** Systematic reviews will be assessed for their methodological quality using the JBI Critical Appraisal Checklist for Systematic Reviews and Research Syntheses. **Data Collection** Data will be extracted from the final list of articles included using the JBI Data Extraction Form for Review for Systematic Reviews and Research Syntheses. **Data Summary** A qualitative synthesis of the findings will be presented in the text and using tables describing study characteristics and the overall umbrella review results (summary of findings). **Anticipated Start Date** February 11th, 2020 **Anticipated Completion Date** April 30th, 2020