## Registered report: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis <br> **Abstract:** The [Reproducibility Project: Cancer Biology][1] seeks to address growing concerns about reproducibility in scientific research by conducting replicating selected results from a number of high-profile papers in the field of cancer biology. The papers, which were published between 2010 and 2012 were selected on the basis of [citations and Altimetric scores][2] ([Errington et al., 2014][3]). This Registered report describes the proposed replication plan of key experiments from ‘Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis’ by Goetz and colleagues, published in *Cell* in 2011 ([Goetz et al., 2011][4]). The key experiments being replicated are those reported in Figures 7C (a-d), Supplemental Figure S2A, and Supplemental Figure S7C (a-c) ([Goetz et al., 2011][4]). In these experiments, which are a subset of all the experiments reported in the original publication, Goetz and colleagues show in a subcutaneous xenograft model that stromal caveolin-1 remodels the intratumoral microenvironment, which is correlated with increased metastasis formation. The Reproducibility Project: Cancer Biology is a collaboration between the [Center for Open Science][6] and [Science Exchange][7], and the results of the replications will be published by [*eLife*][8]. ---------- ### Contents This component contains additional materials relating to the Registered Report for Study 20: Goetz et al. 2010, Cell. The Registered Report can be found [here][9]. **Registered Report Initial Draft**: - This document represents the first draft of the selected experimental protocols. It contains the information that the Core team, with help from scientist volunteers, was able to glean from the original publication and its supplemental materials before the original authors were contacted for their input. - [Study 20 Registered Report Initial Draft][10] **Power Calculations**: - These documents contain details about how power calculations were performed, and include spreadsheets documenting statistical tests as well as any PRISM files, R scripts or additional materials used. - [Study 20 Power Calculations][11] - [Study 20 Spearmann simulation.R][12] - [Data for importing into R for Spearman simulation][13] - [Study 20 primary tumor analysis][14] [1]: https://osf.io/e81xl/wiki/home/ [2]: https://osf.io/e81xl/wiki/studies/ [3]: https://doi.org/10.7554/eLife.04333 [4]: https://doi.org/10.1016/j.cell.2011.05.040 [6]: http://cos.io/ [7]: https://www.scienceexchange.com/ [8]: https://elifesciences.org/ [9]: http://elifesciences.org/content/4/e04796 [10]: https://osf.io/2thbs/ [11]: https://osf.io/7e2y8/ [12]: https://osf.io/pd49w/ [13]: https://osf.io/wp4ry/ [14]: https://osf.io/fhcbm/