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Description: The key questions guiding these living rapid reviews are: KQ1: What is the effectiveness of different COVID-19 rapid testing strategies* including self-administered versus supervised testing, and different testing frequencies (e.g., one off compared to serial testing at different intervals for different lengths of time) at detecting infectiousness or reducing transmission? KQ2: What is the risk of COVID-19 transmission associated with different activities (e.g., dining, exercising etc.) or settings (e.g., educational, hospitality etc.) and what factors contribute to risk (e.g., type of contact, number of contacts, time within the risk environment)? KQ3: How does transmission risk of common activities alter with background population prevalence of SARS-CoV-2 and population vaccine coverage? *This review does not focus on the comparison of rapid antigen detection tests with a reference standard reverse transcription polymerase chain reaction (RT-PCR) test or the choice of individual tests. This research was funded by the Health Research Board through Evidence Synthesis Ireland [HRB Grant Number CBES-2018-001]. The living rapid reviews were also funded by The Strategy for Patient-Oriented Research Evidence Alliance (SPOR EA) which is supported by the Canadian Institutes of Health Research (CIHR) under the Strategy for Patient-Oriented Research (SPOR) initiative.