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<p>Target of replication: <em>A priori</em> experimental protocols for the <em>in vivo</em> portion of the replication, materials, and confirmatory analysis plans were peer reviewed, <a href="https://osf.io/ng3st/" rel="nofollow">pre-registered</a>, and published by <a href="https://elifesciences.org/content/4/e07072" rel="nofollow"><em>eLife</em></a>.</p> <p>This component includes all data, analysis scripts, and methods for the replication of the experiment reported in Figure 7C-E of <a href="http://www.cell.com/cell/abstract/S0092-8674(11)00943-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867411009433%3Fshowall%3Dtrue" rel="nofollow">Delmore et al., 2011</a>. This experiment assesses the effect of JQ1 treatment on tumor growth. </p> <p><a href="https://osf.io/kf7ze/wiki/home/" rel="nofollow">Figures component</a> contains a visualization of replication results. These figures are the same as can be found in the Replication Study and include Figure 2 displaying overall survival and Figure 3 displaying tumor burden. These scripts will call data directly from the OSF.</p> <p><a href="https://osf.io/yznr4/wiki/home/" rel="nofollow">Statistical Analyses component</a> contains R scripts that were used for the analysis. These scripts will call data directly from the OSF.</p> <p><a href="https://osf.io/jse9q/wiki/home/" rel="nofollow">Data component</a> contains data generated from the experimental work and files used in the analysis and generation of figures, which are in .csv format.</p> <p><a href="https://osf.io/pbw39/wiki/home/" rel="nofollow">Methods component</a> contains methodology details for this replication attempt which are described in the <a href="https://elifesciences.org/content/4/e07072" rel="nofollow">Registered Report</a>.</p> <p><a href="https://osf.io/r38p3/wiki/home/" rel="nofollow">Cell line quality control data</a> includes results confirming the cells lines was free from mycoplasma contamination as well as STR DNA profiling of the cell lines used.</p>
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