Target of replication: *A priori* experimental protocols, materials, and confirmatory analysis plans were peer reviewed, [pre-registered][1], and published by [*eLife*][2]. This component includes all data, analysis scripts, and methods for the replication of the experiment reported in Supplemental Figure 4 of [Arthur et al. 2012][3]. This experiment entails the inoculation of germ-free Il10−/− mice with E. coli as well as treatment with the carcinogen azoxymethane (AOM). <br> ### Contents [Figures component][4] contains a visualization of replication results. [Statistical Analyses component][5] contains R scripts that were used for the analysis. [Data component][6] contains data generated from the experimental work and files used in the analysis and generation of figures, which are in .csv format. [Methods component] [Cell line quality control data] [1]: https://osf.io/9gykv/ [2]: http://elifesciences.org/content/4/e04586v1 [3]: http://science.sciencemag.org/content/338/6103/120 [4]: https://osf.io/p3qb5/wiki/home/ [5]: https://osf.io/h7fmw/wiki/home/ [6]: https://osf.io/hyke8/wiki/home/