Experiments 1 & 2: Contrast Sensitivity Function and Visual Acuity ----------------------------------------------------------------- A total of 14 age-matched control participants and 10 patients with keratoconus were tested monocularly under full adaptive optics (AO) correction. **-**Experiment 1:** quick Contrast Sensitivity Function (qCSF)** Spatial frequency (SF) values (in cpd): 0.25, 0.39, 0.60, 0.92, 1.43, 2.20, 3.40, 5.3, 8.13, 12.6, 19.4, 30 **-Experiment 2: high-contrast Snellen letter visual acuity (VA)** ---------- **EXP1-2_DATA_INDIVIDUAL.cvs** **ROWS (#25)** #1: labels\ #2-15: control participants (N=14)\ #16-25: keratoconus participants (N=10) **COLUMNS (#27)** #01: participant ID\ #02: age (years)\ #03: biological sex (M: male; F: female)\ #04: habitual RMS (µm)\ #05: habitual hRMS+ (µm)\ #06: AO-corrected residual RMS (µm)\ #07: visual acuity threshold (logMAR)\ #08: visual acuity threshold (Snellen) qCSF estimates (in logunits)\ #09: amplitude (peak sensitivity)\ #10: peak spatial frequency\ #11: bandwidth\ #12: truncation level at low SF\ #13: low-SF sensitivity\ #14: high-SF cutoff\ #15: AUCSF\ #16-27: contrast sensitivity estimates at each of the 12 spatial frequencies (SFs) ---------- **EXP1-2_DATA_GROUP.cvs** **ROWS (#6)** #1: labels\ #2: control group (N=14)\ #3: keratoconus group (N=10)\ #4: mild keratoconus (N=3)\ #5: moderate keratoconus (N=4)\ #6: severe keratoconus (N=3) **COLUMNS (#63)** #01: group ID\ #02: habitual RMS (µm)\ #03: habitual hRMS+ (µm)\ #04: AO-corrected residual RMS (µm)\ #05: visual acuity threshold (logMAR)\ #06: visual acuity threshold (Snellen) qCSF estimates [with 95% confidence intervals] (in logunits)\ #07-09: amplitude [95% CI]\ #10-12: peak spatial frequency [95% CI]\ #13-15: bandwidth [95% CI]\ #16-18: truncation level at low SF [95% CI]\ #19-21: low-SF sensitivity [95% CI]\ #22-24: high-SF cutoff [95% CI]\ #25-27: AUCSF [95% CI] contrast sensitivity estimates at each of the 12 spatial frequencies (SFs)\ #28-39: contrast sensitivity estimates\ #40-51: lower 95%-CI estimates\ #52-63: upper 95%-CI estimates Experiment 3: Equivalent noise paradigm & Perceptual Template Model ----------------------------------------------------------------- 8 age-matched control participants and 6 keratoconus patients were tested monocularly under full adaptive optics (AO) correction. The Perceptual Template Model was used to characterize the sources of inefficiencies mediating contrast sensitivity differences between groups (control N=8, mild/moderate keratoconus N=3, severe keratoconus N=3). ---------- **EXP3_DATA_SFXX.cvs** [5 files] Individual and group-average contrast thresholds estimates for each of the spatial frequency tested (0.5, 1, 3, 9, and 16 cpd)\ 70.71%-correct and 79.37%-correct thresholds were measured as a function of the level of external noise added to the stimulus target. external noise levels: 0, 0.021, 0.041, 0.083, 0.124, 0.165, 0.248, 0.33 **ROWS (#18)** #1: labels\ #2-9: control participants\ #10-15: keratoconus participants\ #16: control group (N=6)\ #17: severe keratoconus group (N=3)\ #18: mild/moderate keratoconus participants (N=3) **COLUMNS (#20)** #01: group ID\ #02: participant ID\ #03: habitual RMS (µm)\ #04: habitual hRMS+ (µm)\ #05-12: 70.71%-correct thresholds at each of the 8 external noise levels\ #13-20: 79.37%-correct thresholds at each of the 8 external noise levels ---------- **EXP3_ModelComparison_XX.cvs** [3 files] Summary of the results for each of the 8 possible variants of the PTM for:\ 1. main (data from all 5 SFs) 2. low-SF data (0.5 and 1 cpd only) 3. high-SF data (9 and 16 cpd only) **ROWS (#9)** #1: labels\ #2: null model\ #3: internal additive noise model (Aadd)\ #4: multiplicative internal noise model (Amul)\ #5: external noise filtering model (Aext)\ #6: mixture model (Aadd + Amul)\ #7: mixture model (Aext + Amul)\ #8: mixture model (Aext + Aadd)\ #9: full model (Aadd + Amul + Aext) **COLUMNS (#5)** #01: model ID\ #02: delta BIC\ #03: variance explained (r2)\ #04: residual sum of squares (RSS)\ #05: number of free parameters (k) ---------- **EXP3_IndividualEstimates.cvs** Individual parameter estimates at low and high SFs **ROWS (#15)** #1: labels\ #2-9: control participants\ #10:15: keratoconus patients **COLUMNS (#9)** #01: participant ID\ #02: habitual RMS (µm)\ #03: habitual hRMS+ (µm)\ #04: internal additive noise – low SF\ #05: internal additive noise – high SF\ #06: external noise filtering – low SF\ #07: external noise filtering – high SF\ #08: multiplicative internal noise – low SF\ #09: multiplicative internal noise – high SF\