Dr. Zelinski’s research centers on understanding the development and function of primate ovarian follicles, incorporating nonhuman primates as pre-clinical models for infertility, contraception, fertility preservation and ovarian aging as related to women’s reproductive health. The primary goal of oncofertility research in the Zelinski lab is to merge the principles of tissue engineering and biomaterial science with ovarian biology to develop novel fertility preservation options for girls and young women who must undergo treatments that threaten their fertility. The rhesus monkey is being used as a model for ovarian protection, ovarian transplantation and 3-dimensional follicle culture as strategies for fertility preservation. These experiments will be translated to the human clinic to offer ovarian follicle maturation before or after cryopreservation as fertility preservation options for cancer survivors. More recent research is focused on pre-clinical trials in the rhesus monkey to test the in vivo efficacy of a potential intervention for ovarian aging. Endpoints include evaluating the primordial follicle ovarian reserve, indicators of ovarian follicular health, oocyte quality and competence, as well as metabolic and immune functions in both young and aging macaques. https://www.ohsu.edu/people/mary-b-zelinski-phd For initial dissemination of ovary histology slides, the MOTHER project used the ASU Library Research Data Repository to store the Zelinkski Lab Macaque Ovary images and metadata (version 1.0) (https://dataverse.asu.edu/dataverse/MOTHER). See the Wiki for each species for a direct link to its dataset on the ASU Library Research Data Repository. Please visit the MOTHER Web site (https://mother-db.org) for the searchable repository of ovary histology images. The OSF linking to a Dataverse storage add-on does not appear to be stable, and is currently not being utilized. However, each species OSF component has populated the limited OSF storage with at least 2 images and its associated XML metadata file, which are in MOTHER Version 1.0 format. MOTHER uses eml for data provenance and includes the MOTHER metadata in eml's additional metadata tag. The ome.tif file is the full size file, which can be quite large. There is an associated _reduced.tif file, which is the image reduced to 10% of its original size. Similarly, _thumbnail.tif provides a small, thumbnail image of the slide.