Econometric Issues in Prospective Economic Evaluations of Substance Use Disorder Interventions Alongside Clinical Trials: Combining the Nonparametric Bootstrap with Methods that Address Missing Data

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Background/Objectives. Missing data bias and sampling uncertainty are common concerns in randomized controlled trials (RCT). Widely-recommended methods that address missingness and sampling uncertainty have been studied extensively by themselves and in the context of economic evaluations conducted alongside RCTs. However, little is known on how to appropriately combine these methods, and the poten...

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