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Description: Understanding the emotional responsivity style and neurocognitive profiles of depression-related processes in at-risk youth may be helpful in predicting those most likely to develop affective disorders. However, the multiplicity of biopsychosocial risk factors makes it difficult to disentangle unique and combined effects at a biological level. In a sample of 56 older adolescents recruited as part of a population-representative longitudinal cohort study of adolescent emotional development, we adopted Partial Least Squares regression and correlation models to explore the relationships between multivariate biopsychosocial risks for later depression, emotional response style and fMRI activity, to rejecting and inclusive social feedback, using a social evaluation paradigm. Behaviorally, higher depressive risk was associated with both reduced negative affect following negative social feedback and reduced positive affect following positive social feedback, supporting the notion of Emotion Context Insensitivity in at-risk youth. In response to both cues of rejection and inclusion, we observed a general neural pattern of increased cingulate, temporal and striatal activity in the brain, and showed a specific relationship between presence of Childhood Adversity and increased caudate activity. Secondly, in response to rejection only, we observed a pattern of activity in ostensibly executive control- and emotion regulation-related brain regions encompassing fronto-parietal brain networks including the angular gyrus. We investigated the relationship between multivariate depressive risk and emotional response style, and latent brain-behavior relationships of neurocognitive activation patterns, during a social evaluation task. The results suggest that risk for depression is associated with a pervasive emotional insensitivity in the face of positive and negative social feedback.