## Abstract ## **Background:** Addiction is a neurodevelopmental disease with public health concern and lacking of efficiency treatment. The mechanism and treatment targets of addiction are urgently awaited to be developed using neuroimaging method such as resting-state fMRI (rs-fMRI). However, the majority problem of current studies is the small sample number and lower repeatability. The meta-analysis approach can help to shed light on the abnormity of addiction from R-fMRI perspective. **Methods:** We used ES-SDM method to combine the results of individual studies of the regional homogeneity (ReHo), and the amplitude of low frequency fluctuations (ALFF), fractional ALFF (fALFF) in addicts, compare with healthy controls. By selecting 28 studies which all use the voxel-wise whole brain two-sample comprise method. We divided them into 2 separate meta-analysis, ReHo and ALFF/fALFF. **Results:** In addicts, compare with healthy controls, we found a significant increased ReHo and ALFF in the left supplementary motor area and bilateral median cingulate, decreased ReHo and ALFF in right middle superior frontal gyrus. We also found increased ReHo in left precentral gyrus, left postcentral gyrus, right inferior temporal gyrus, and left middle temporal gyrus; decreased ReHo in the bilateral anterior cingulate, medial orbitofrontal cortex, bilateral ventromedial prefrontal cortex, and right dlPFC. We found increased ALFF/fALFF in right putamen, right insula, bilateral thalamus; decreased ALFF/fALFF in left middle occipital gyrus **Discussion:** Therefore, our two meta-analyses may indicate the abnormal prefrontal subcortical circuits for addicts from two domains. These findings may identify potential frontal targets for current noninvasive brain stimulation methods such as TMS. **Keywords**: addiction, Resting-state fMRI, ReHo, ALFF, meta-analysis