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Association between CD4 T cell counts and the immune status among adult critically ill HIV-negative patients in intensive care units in Uganda
- KAVUMA ARTHUR MWANJE
- KWIZERA ARTHUR
- ANDIA BIRARO IRENE
- KIZITO SAMUEL
- EJOKU JOSEPH
- SSEMOGERERE LAMECK
- LUBULWA CLARE
- WABULE AGNES
- LUBIKIRE AGGREY
- OKELLO ERASMUS
- SENDAGIRE CORNELIUS
- NAMATA CHRISTINE
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Description: Background: Cluster of differentiation 4 (CD4) T cells play a central role in regulation of adaptive T cell-mediated immune responses. Low CD4 T cell counts are not routinely reported as a marker of immune deficiency among HIV-negative individuals, as is the norm among their HIV positive counterparts. Despite evidence of mortality rates as high as 40% among Ugandan critically ill HIV-negative patients, the use of CD4 T cell counts as a measure of the immune status has never been explored among this population. This study assessed the immune status of adult critically ill HIV-negative patients admitted to Ugandan intensive care units (ICUs) using CD4 T cell count as a surrogate marker.
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