Association between CD4 T cell counts and the immune status among adult critically ill HIV-negative patients in intensive care units in Uganda

Contributors:
  1. KWIZERA ARTHUR
  2. ANDIA BIRARO IRENE
  3. KIZITO SAMUEL
  4. EJOKU JOSEPH
  5. LUBULWA CLARE
  6. WABULE AGNES
  7. LUBIKIRE AGGREY
  8. OKELLO ERASMUS

Date created: | Last Updated:

: DOI | ARK

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Category: Project

Description: Background: Cluster of differentiation 4 (CD4) T cells play a central role in regulation of adaptive T cell-mediated immune responses. Low CD4 T cell counts are not routinely reported as a marker of immune deficiency among HIV-negative individuals, as is the norm among their HIV positive counterparts. Despite evidence of mortality rates as high as 40% among Ugandan critically ill HIV-negative patients, the use of CD4 T cell counts as a measure of the immune status has never been explored among this population. This study assessed the immune status of adult critically ill HIV-negative patients admitted to Ugandan intensive care units (ICUs) using CD4 T cell count as a surrogate marker.

License: CC0 1.0 Universal

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