**Overview** ------------ This repository includes all data and analysis code needed to generate the results and figures presented in the following manuscript: Convertino L, Bush D, Zheng F, Adams RA, Burgess N (2022) Reduced grid-like theta modulation in schizophrenia. Brain https://academic.oup.com/brain/advance-article/doi/10.1093/brain/awac416/6815801 **Instructions** ---------------- The main analysis pipeline can be executed using the 'pipeline' script in Matlab. This script calls a series of other functions that run each stage of the analysis in turn. Note that both SPM 12 and the DAiSS toolbox are needed to run these analyses: https://www.fil.ion.ucl.ac.uk/spm/software/spm12/ https://github.com/spm/DAiSS **Abstract** ------------ The hippocampal formation has been implicated in the pathophysiology of schizophrenia, with patients showing impairments in spatial and relational cognition, structural changes in entorhinal cortex, and reduced theta coherence with medial prefrontal cortex. Both the entorhinal cortex and medial prefrontal cortex exhibit a six-fold (or ‘hexadirectional’) modulation of neural activity during virtual navigation that is indicative of grid cell populations and associated with accurate spatial navigation. Here, we examined whether these grid-like patterns are disrupted in schizophrenia. We asked 17 participants with diagnoses of schizophrenia and 23 controls (matched for age, sex and IQ) to perform a virtual reality spatial navigation task during magnetoencephalography. The control group showed stronger 4-10 Hz theta power during movement onset, as well as hexadirectional modulation of theta band oscillatory activity in the right entorhinal cortex whose directional stability across trials correlated with navigational accuracy. This hexadirectional modulation was absent in patients, with a significant difference between groups. These results suggest that impairments in spatial and relational cognition associated with schizophrenia may arise from disrupted grid firing patterns in entorhinal cortex. **Contact** ------- Any queries, issues, or bugs should be directed to Daniel Bush: drdanielbush@gmail.com