Title: Exploring the Universe with the James Webb Space Telescope Abstract: The James Webb Space Telescope was the primary large mission to be advocated as a result of the 2000 Decadal Survey, and the 2010 Decadal Survey affirmed the role of JWST in shaping the astrophysics questions in the next decade, with a launch date in 2018. It is often labelled as a successor to the Hubble Space Telescope, although working at near- and mid-infrared wavelengths. The combination of sensitivity and resolution make JWST a formidable facility to tackle the most pressing scientific problems in astrophysics, from studying the Universe’s first stars and galaxies, mapping the evolution of galaxies across cosmic time, performing detailed characterization of exoplanet atmospheres, and studying the formation of Solar Systems. JWST contains a new generation of complex instrumentation to ensure diverse modes of operation without servicing, including new science modes flown in space for the first time. In this talk I will describe the instruments and observing! modes on JWST, and lay the groundwork for expected science discoveries with JWST. I will describe current elements of the mission timeline that lead up to a scheduled launch in October 2018, as well as steps being taken by both zNASA and ESA to prepare the astronomy community to use JWST and maximize its full potential for science. I will describe synergies with current and planned telescopes in the radio, mm and sub-mm wavelength range, and discuss how to best utilize investments in these areas to maximize science.