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Description: The objective of the present study was to examine whether different methods for dealing with dependency in meta-analytic structural equation modelling (MASEM) lead to different results. Four different methods for dealing with dependent effect sizes in MASEM were applied to empirical data, including: (1) ignoring dependency; (2) aggregation; (3) elimination; and (4) a multilevel approach. Random-effects two-stage structural equation modelling was conducted for each method separately, and potential moderators were examined using subgroup analysis. Results demonstrated that the different methods of dealing with dependency in MASEM lead to different results. Thus, the decision on which approach should be used in MASEM-analysis should be one that is carefully considered. Given that the multilevel approach is the only approach that includes all available information while explicitly modelling dependency, it is currently the theoretically preferred approach for dealing with dependency in MASEM. Future research should evaluate the multilevel approach with simulated data.