This presentation summarizes the relationship between 3-way of predictors, including religiosity (personal importance or attendance), gender(male or female)/race (White, Black, or Hispanic), and the third sociodemographic variable, and dichotomized (never versus any use) self-reported use of different substances within different timeframes (lifetime, last 12 months, last 30 days) in Monitoring the Future study (2016, 12th-grade, Form 2). It was presented for the 2020 Division 36 Mid-Year Conference in Denver, CO.