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Category: Project

Description: With concerns over research reproducibility on the rise, systematic replications of published science have become an important tool to estimate the replicability of findings in specific areas. Nevertheless, such initiatives are still uncommon in biomedical science, and have never been performed at a national level. The Brazilian Reproducibility Initiative is a multicenter effort to assess the reproducibility of the country’s biomedical research by replicating 60 experiments from Brazilian life sciences articles. The project will focus on 3 common laboratory methods - MTT assays, RT-PCR and the elevated plus maze - and each experiment will be performed in 3 different labs within a network of more than 50 labs across the country. The reproducibility of published findings will be analyzed in the light of interlaboratory variability, using meta-analysis of the results to measure replicability using different predefined criteria. The results, due in mid-2023, will allow us not only to estimate the reproducibility of Brazilian biomedical science, but also to investigate if there are aspects of the published literature that can be used to predict it.