This repository contains results from the following paper:
*A human brain network linked to restoration of consciousness after deep brain stimulation*
Aaron E.L. Warren, Marina Raguž, Helen Friedrich, Frederic L.W.V.J. Schaper, Jordy Tasserie, Samuel B. Snider, Jian Li, Melissa M.J. Chua, Konstantin Butenko, Maximilian U. Friedrich, Rohan Jha, Juan E. Iglesias, Patrick W. Carney, David Fischer, Michael D. Fox, Aaron D. Boes, Brian L. Edlow, Andreas Horn, Darko Chudy, John D. Rolston
Contact: awarren15@bwh.harvard.edu
Contents:
- **Optimal stimulation sites ("sweet spot" analysis; DBS_DoC_OptimalStimSite.nii.gz)**: Unthresholded NIfTI file containing results of the optimal stimulation site mapping, comparing stimulation electric fields (E-fields) between improved and non-improved groups (as visualized in Figure 3C of the manuscript). Results are t-scores, where positive values indicate locations where E-field magnitudes were higher in the improved group relative to the non-improved group, and negative values indicate the opposite. Data are provided in MNI152 ICBM 2009b nonlinear asymmetric template space.
- **Optimal structural connectivity ("fiber filtering" analysis; DBS_DoC_OptimalStructConn.nii.gz)**:
NIfTI file containing results of the optimal structural connectivity analysis, assessing white matter fiber connections more strongly involved in the improved group relative to the non-improved group (as visualized in Figure 4 of the manuscript). Results are fiber counts, where voxels are weighted by the number of therapeutically optimal streamlines passing through each voxel. Data are provided in MNI152 ICBM 2009b nonlinear asymmetric template space.
- **Optimal functional connectivity (*.fsaverage.OptimalFuncConn.func.gii)**: Unthresholded scalar overlay (GIfTI) files for the left (lh) and right (rh) hemispheres, containing results of the optimal functional (fMRI) connectivity analysis. This identifies cortical regions more strongly connected to stimulation sites in patients who improved relative to those who did not (as visualized in Figure 5A of the manuscript). Values are t-scores, where positive values indicate stronger DBS site-related functional connectivity in the improved group, and negative values indicate the opposite. Files are in FreeSurfer’s fsaverage surface space.
