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Where to place the rewards? Exploration bias in mice influences performance in the classic hole-board spatial memory test.
- Patricia Sampedro-Piquero
- María del Carmen Mañas-Padilla
- Fabiola Ávila-Gámiz
- Sara Gil-Rodríguez
- Luis Santín
- Estela Castilla-Ortega
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Description: The classic hole-board paradigm (a squared arena with 16 holes arranged equidistantly in a 4 x 4 pattern) assesses both exploration and spatial memory in rodents. For spatial memory training, food rewards are hidden in a fixed set of holes. The animal must not re-visit a baited hole within a session (working memory) nor explore those holes that are never baited (reference memory). However, previous exploratory bias may affect performance during reward searching and consequently on memory scores. According to this, there is no consensus on where to place the rewards in a hole-board arena. This aspect has been given scarce importance, to the point that rewards’ location is frequently omitted from the methods description of hole-board manuscripts. Therefore, in this project, we study if intrinsic exploratory bias and rewards’ location influence memory-related measures in mice assessed in a ‘classic 16-hole’ hole-board apparatus.
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