Target of replication: *A priori* experimental protocols, materials, and confirmatory analysis plans were peer reviewed, [pre-registered][1], and published by [*eLife*][2]. This component includes all primary data, analysis scripts, and QC data for the replication of the experiment reported in Figure 3B and S6B-C of [Berger et al., 2012][3]. This experiment was performed to assess the impact of PREX2 expression on tumor growth and tumor free survival in mice injected with NRAS^G12D melanocytes stabily expressing GFP, PREX2^WT, PREX2^G844D, or PREX2^Q1430*. ## Contents [Figures Component][4] contains a visualization of replication results. These figures are the same as can be found in the Replication Study and include Figures 3 and 4. [Statistical Analyses Component][5] contains R scripts that were used for the analysis. [Data Component][6] contains data generated from the experimental work and files used in the analysis and generation of figures, which are in .csv format. [Methods Component][7] contains methodology details for this replication attempt which were described in the [Registered Report][2]. [Cell line quality control data][8] includes results confirming the cell lines were free of mycoplasma contamination as well as STR DNA profiling of the cell lines used. [1]: https://osf.io/rvyg5/ [2]: https://elifesciences.org/content/3/e04180 [3]: http://www.nature.com/nature/journal/v485/n7399/full/nature11071.html [4]: https://osf.io/pqyks/wiki/home/ [5]: https://osf.io/z9mhg/wiki/home/ [6]: https://osf.io/jvra5/wiki/home/ [7]: https://osf.io/gnm64/wiki/home/ [8]: https://osf.io/dhch3/wiki/home/