Presentation Abstract: Introduction: Regular physical activity (PA) and decreased sedentary behaviors (SB) slow physical decline and improve quality of life (QoL). However, limited research has been conducted examining PA interventions for adults with aphasia (AWA). Aphasia is an acquired language disorder affecting ~2.5 million people in the U.S. The present study aims to evaluate the feasibility and effectiveness of an aphasia-friendly exercise class on QoL, PA, and SB. Methods: QoL assessments were performed pre- and post-intervention in eleven participants (55% female); age mean(SD): 62(14) years. Nine enrolled in the exercise class, and the two in the comparison group, did not. 10 weeks of twice-weekly, 50-minute exercise sessions consisting of range of motion, aerobic, muscular endurance and strength were conducted via Zoom. Free-living, PA data was collected using activPAL 4+ (thigh-worn [on most active leg]) for 7-consecutive days at pre- and post-intervention. Valid wear days (≥ 4 days with ≥ 10 hrs. of waking wear) were examined. Paired- and two-sample t-tests were used to examine participant average change and mean group differences, respectively, significance set at p<0.05. Results: AWA were able to participate in the exercise classes and average attendance was high (80%). The Burden of Stroke (BOSS) “positive emotions” subscore improved significantly for the exercise but not the comparison group (p=0.04). Discussion: AWA may benefit from virtual, aphasia-friendly interventions aimed to improve QoL, increase PA, and decrease SB. Albert R. Mendoza, Ph.D. (he/him) Why include my pronouns? From the NIH Office of Equity, Diversity and Inclusion: https://www.edi.nih.gov/blog/communities/what-are-gender-pronouns-why-do-they-matter Assistant Professor, Department of Kinesiology California State University, East Bay 25800 Carlos Bee Blvd. Hayward, CA 94542 "No problem can withstand the assault of sustained thinking.” -Voltaire