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<p>This component includes data and analysis scripts for the meta-analyses of the effects from the experiment reported in Figures 3B and 7C-E of <a href="http://www.cell.com/cell/abstract/S0092-8674%2811%2900943-3?_returnURL=http://linkinghub.elsevier.com/retrieve/pii/S0092867411009433?showall=true" rel="nofollow">Delmore et al., 2011</a> and the replication of these experiments.</p> <p><strong>Figure 4. Meta-analyses of each effect.</strong> Effect size and 95% confidence interval are presented for Delmore et al., 2011, this replication study (RP:CB), and a random effects meta-analysis of those two effects. Sample sizes used in Delmore et al., 2011 and this replication attempt are reported under the study name. (<strong>A</strong>) Relative <em>MYC</em> expression in MM.1S-luc cells treated with 500 nM (+)-JQ1 for 8 hr compared to 0 hr (<em>p</em> = .224), and the comparison between (+)-JQ1 treatment for 1 hr to 0 hr (<em>p</em> = .155). (<strong>B</strong>) Tumor burden, determined by bioluminescence at day 22, in mice bearing MM.1S-luc tumors and treated daily with 50 mg/kg (+)-JQ1 or vehicle control (<em>p</em> = .110). (C) HR for mice treated daily with 50 mg/kg (+)-JQ1 compared to vehicle control (<em>p</em> = .0112). </p> <p>Access the <a href="https://osf.io/465r3/" rel="nofollow">full size image</a> and <a href="https://osf.io/37vnt/" rel="nofollow">R script</a> used to generate this figure. These scripts will call the <a href="https://osf.io/qvtnj/" rel="nofollow">data</a> directly from the OSF.</p> <p>Access the <a href="https://osf.io/x6g87/" rel="nofollow">analysis script</a>. This script will call the data directly from the OSF for the replication data.</p>
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