Main content



Loading wiki pages...

Wiki Version:
This component includes data and analysis scripts for the meta-analyses of the effects from the experiment reported in Figures 3B and 7C-E of [Delmore et al., 2011][1] and the replication of these experiments. **Figure 4. Meta-analyses of each effect.** Effect size and 95% confidence interval are presented for Delmore et al., 2011, this replication study (RP:CB), and a random effects meta-analysis of those two effects. Sample sizes used in Delmore et al., 2011 and this replication attempt are reported under the study name. (**A**) Relative _MYC_ expression in MM.1S-luc cells treated with 500 nM (+)-JQ1 for 8 hr compared to 0 hr (*p* = .224), and the comparison between (+)-JQ1 treatment for 1 hr to 0 hr (*p* = .155). (**B**) Tumor burden, determined by bioluminescence at day 22, in mice bearing MM.1S-luc tumors and treated daily with 50 mg/kg (+)-JQ1 or vehicle control (*p* = .110). (C) HR for mice treated daily with 50 mg/kg (+)-JQ1 compared to vehicle control (*p* = .0112). Access the [full size image][2] and [R script][3] used to generate this figure. These scripts will call the [data][4] directly from the OSF. Access the [analysis script][5]. This script will call the data directly from the OSF for the replication data. [1]: [2]: [3]: [4]: [5]:
OSF does not support the use of Internet Explorer. For optimal performance, please switch to another browser.
This website relies on cookies to help provide a better user experience. By clicking Accept or continuing to use the site, you agree. For more information, see our Privacy Policy and information on cookie use.

Start managing your projects on the OSF today.

Free and easy to use, the Open Science Framework supports the entire research lifecycle: planning, execution, reporting, archiving, and discovery.