In the light of a meta-analysis on **drug-induced reactivation-dependent amnesia for contextual fear memories in rodents** (see https://osf.io/yab5k for the Stage 1 RR), often referred to as **reconsolidation blockade**, we are looking for **unpublished data** meeting all of the following criteria:
(1) Population: rats or mice of either sex
(2) Intervention: **contextual fear conditioning** (i.e., one or multiple unsignaled shock(s) are administered in the training context) and **anisomycin, midazolam, propranolol, or MK-801** is given intracranially or systemically once before or after a brief unreinforced re-exposure to the previously-conditioned context
(3) Control group: experiments include a negative control group in which subjects receive a memory reactivation session combined with vehicle administration or in which the drug of interest is administered without receiving a memory reactivation session
(4) Outcomes: a behavioral measure of fear or anxiety (e.g., freezing) is included during drug-free testing for long-term memory retention at least one day after reactivation
(5) The amnestic procedure occurs **under standard conditions** (e.g., no additional interventions are applied to prevent, amplify or rescue an amnestic effect), and an amnestic effect was a priori expected to occur under those conditions
- memories should be recent (<7 days after acquisition training) at the time of reactivation
- the duration of the reactivation session should be less than two times the duration of the acquisition session
- treatment should be applied shortly before/after the memory reactivation session (not > 1h before/after)
The ultimate aim of the meta-analysis is to get some insight on the variability of reactivation-dependent amnesia using contextual fear conditioning in rodents. **Please let us know if you are willing to contribute by e-mailing to natalie.schroyens@kuleuven.be**. We would highly appreciate your interest and contribution.
We plan to finish data collection before the end of September 2020.
Laura Luyten, Tom Beckers, Wim Van Den Noortgate, Eric Sigwald and Natalie Schroyens
