Our current UO1, which is responsive to PAR-14-067, Impact of Affect Reactivity and Regulation on Breast Cancer Treatment Decisions, was designed to identify the affective basis of these important treatment decisions, leading to more effective decision support and treatment. This U01 currently has three specific aims, as follows: Specific Aim 1. Examine affect reactivity and regulation among women with a recent diagnosis of breast cancer in comparison to healthy controls. Specific Aim 2. Relate affect reactivity and regulation to choice of BLM. Specific Aim 3 (Secondary). Assess long term functioning correlates of BLM decision and affect reactivity and regulation. As proposed, our fMRI analyses focus on brain regions that control cognition (the prefrontal cortex, PFC), context assessment (anterior cingulate cortex, ACC), and emotion (the amygdala). Emotional reactivity is enhanced by lower ACC function. (9-11). Similar brain regions are involved in conscious regulation of emotion (12, 13) This interaction of cognition, contextual awareness, and emotion helps to explain the role of emotional discomfort in reaching cancer treatment decisions. We hypothesize that weak affect regulation combined with strong affect reactivity allows emotions such as anxiety to dominate decision-making.