### Abstract Citizen Science has come up to perform analytics over the SARS-CoV-2 genome. Public GALAXY servers provide an automated platform for genomics analysis. Study includes design of GALAXY workflows for RNASEQ assembly and annotation as well as genomic variant discovery and perform analysis across four samples of SARS-CoV-2 infected humans obtained from the local population of Wuhan, China. It provides information about transcriptomics and genomic variants across the SARS-CoV-2 genome. Study can be extended to perform evolutionary and comparative study across each species of coronaviruses. Augmented and integrated study with cheminformatics and immunoinformatics will be a way forward for drug discovery and vaccine development. ### Background SARS-CoV-2 outbreak has brought the community researchers all together. Publicly accessible computational platforms like public GALAXY servers are providing web-accessible resources for community research. Available tools in the GALAXY tools shed enable users to perform integrated analysis of SARS-CoV-2 genome - Genomics, Cheminformatics, Immunoinformatics, Genomic Variant Discovery, Phylogenomics etc. Present study is an analysis of the SARS-CoV-2 genome - assembly, annotation and genomic variants discovery. It will provide an insight into the SARS-CoV-2 genome and will help to understand the functioning and adaptation of SARS-CoV-2 virus inside its host. Further, impact of the SARS-CoV-2 virus is very specific to the population. An automated and reproducible pipeline for integrative study of Genomics, Cheminformatics and immunoinformatics of SARS-CoV-2 infection will pave the path for population specific vaccine development. GALAXY can be developed as a dedicated workbench for all possible analysis of viruses belonging to the coronaviruses family.