Human Data were obtained from patients recorded during their pre-surgical workup at Motol Epilepsy Center in Prague, Czech Republic, between 2009 and 2017. Data were recorded using depth macroelectrodes (Dixi Medical or Ad-Tech) in the referential montage using Stellate Harmony (sampling frequency 1 kHz) or Natus NicOne (sampling frequency 512 Hz). The study has been performed in accordance with the Declaration of Helsinki and ethical approval was granted by the Ethical committee of Motol University Hospital and written informed consent was obtained from all subjects. For the study, patients were retrospectively selected based on their type of epilepsy (temporal lobe epilepsy), that they had at least one resected channel in hippocampus and had excellent surgery outcome (Engel Ia two years after surgery). In those patients, data were selected from each recorded seizure, particularly the time interval ranging from one minute before the start to one minute after the end of the seizure, from a hippocampal and resected channel in hippocampal structure CA1. For more details and individual patient characteristics see the paper manuscript. Rat Data were obtained from male Wistar rats (appr. 200g) that underwent the following procedure. Animals were anesthetized (ketamine 80 mg/kg, xylazine 25 mg/kg) and then decapitated. The brains were removed from the skull and placed into ice-cold, oxygenated protective solution sucACSF (containing in mMol 189 Sucrose, 2.5 KCl, 0.1 CaCl2, 5 MgCl2, 26 NaHCO3, 1.25 NaH2PO4*H20 and 10 glucose). Brain was cut in the sagital plain into slices of 350 μm thickness using a vibratome (Campden Instruments, Loughborough, UK). The hippocampus was cropped and CA3 area was cut off. The hippocampal slices were stored, at room temperature, in a holding chamber filled with "normal" ACSF consisting of (in mMol) 125 NaCl, 26 NaHCO3, 3 KCl, 2 CaCl2, 1 MgCl2, 1.25 NaH2PO4, and 10 glucose, aerated with a humidified 95% O2 – 5% CO2 mixture. After >60 min, slices were transferred to an oxygenated interface recording chamber (34 ± 1°C) where they were constantly superfused with normal ACSF. Local field potentials were recorded using extracellular glass microelectrodes (diameter 10 - 15 μm) filled with ACSF. Signals were amplified (AC/DC Differential Amplifier Model 3000, A-M Systems, Inc., Carlsborg, Washington, USA) and digitized (Power1401, CED, Cambridge, England) with sampling frequency of 10 kHz and stored using Spike 2 for further analysis. The slices were left for at least 10 min in the recording chamber to accommodate. Then, the recording electrode was put on stratum pyramidale. For spontaneous seizures to emerge we increased the K+ concentration by adding KCl solution in large steps (1 - 3 mMol) until a total concentration of 6.5 - 7 mMol was reached. Then we increased the concentration further in small steps (0.2 - 0.5 mMol) until spontaneous seizure-like events occurred. All experimental procedures were approved by the Ethics Committee of The Czech Academy of Sciences. The data files are in matlab format and include the recorded time series ('data'), sampling frequency ('fs'), and additional info (data_info), such as an individual's ID (data_info.ratID: "rat1") or whether or not the selected channel in the human sample was resected during surgery or not (data_info.RES_channel: "1", with 1: yes and 0: no).